The following query was used to determine what twins should be studied further after a initial screening. This was written around 1997 using MySQL 3.19.

SELECT
    CONCAT(p1.id, p1.tvab) + 0 AS tvid,
    CONCAT(p1.christian_name, ' ', p1.surname) AS Name,
    p1.postal_code AS Code,
    p1.city AS City,
    pg.abrev AS Area,
    IF(td.participation = 'Aborted', 'A', ' ') AS A,
    p1.dead AS dead1,
    l.event AS event1,
    td.suspect AS tsuspect1,
    id.suspect AS isuspect1,
    td.severe AS tsevere1,
    id.severe AS isevere1,
    p2.dead AS dead2,
    l2.event AS event2,
    h2.nurse AS nurse2,
    h2.doctor AS doctor2,
    td2.suspect AS tsuspect2,
    id2.suspect AS isuspect2,
    td2.severe AS tsevere2,
    id2.severe AS isevere2,
    l.finish_date
FROM
    twin_project AS tp
    /* For Twin 1 */
    LEFT JOIN twin_data AS td ON tp.id = td.id
              AND tp.tvab = td.tvab
    LEFT JOIN informant_data AS id ON tp.id = id.id
              AND tp.tvab = id.tvab
    LEFT JOIN harmony AS h ON tp.id = h.id
              AND tp.tvab = h.tvab
    LEFT JOIN lentus AS l ON tp.id = l.id
              AND tp.tvab = l.tvab
    /* For Twin 2 */
    LEFT JOIN twin_data AS td2 ON p2.id = td2.id
              AND p2.tvab = td2.tvab
    LEFT JOIN informant_data AS id2 ON p2.id = id2.id
              AND p2.tvab = id2.tvab
    LEFT JOIN harmony AS h2 ON p2.id = h2.id
              AND p2.tvab = h2.tvab
    LEFT JOIN lentus AS l2 ON p2.id = l2.id
              AND p2.tvab = l2.tvab,
    person_data AS p1,
    person_data AS p2,
    postal_groups AS pg
WHERE
    /* p1 gets main twin and p2 gets his/her twin. */
    /* ptvab is a field inverted from tvab */
    p1.id = tp.id AND p1.tvab = tp.tvab AND
    p2.id = p1.id AND p2.ptvab = p1.tvab AND
    /* Just the screening survey */
    tp.survey_no = 5 AND
    /* Skip if partner died before 65 but allow emigration (dead=9) */
    (p2.dead = 0 OR p2.dead = 9 OR
     (p2.dead = 1 AND
      (p2.death_date = 0 OR
       (((TO_DAYS(p2.death_date) - TO_DAYS(p2.birthday)) / 365)
        >= 65))))
    AND
    (
    /* Twin is suspect */
    (td.future_contact = 'Yes' AND td.suspect = 2) OR
    /* Twin is suspect - Informant is Blessed */
    (td.future_contact = 'Yes' AND td.suspect = 1
                               AND id.suspect = 1) OR
    /* No twin - Informant is Blessed */
    (ISNULL(td.suspect) AND id.suspect = 1
                        AND id.future_contact = 'Yes') OR
    /* Twin broken off - Informant is Blessed */
    (td.participation = 'Aborted'
     AND id.suspect = 1 AND id.future_contact = 'Yes') OR
    /* Twin broken off - No inform - Have partner */
    (td.participation = 'Aborted' AND ISNULL(id.suspect)
                                  AND p2.dead = 0))
    AND
    l.event = 'Finished'
    /* Get at area code */
    AND SUBSTRING(p1.postal_code, 1, 2) = pg.code
    /* Not already distributed */
    AND (h.nurse IS NULL OR h.nurse=00 OR h.doctor=00)
    /* Has not refused or been aborted */
    AND NOT (h.status = 'Refused' OR h.status = 'Aborted'
    OR h.status = 'Died' OR h.status = 'Other')
ORDER BY
    tvid;

Some explanations:

This query demonstrates, among other things, how to do lookups on a table from the same table with a join (p1 and p2). In the example, this is used to check whether a twin's partner died before the age of 65. If so, the row is not returned.

All of the above exist in all tables with twin-related information. We have an index on both id, tvab (all tables), and id, ptvab (person_data) to make queries faster.

When we did this work, our production machine was a 200MHz UltraSPARC, and on that old hardware this query returned about 150–200 rows in less than one second. The main table had 70k Rows.